The MOUSE ANTI SHEEP CD230 (PrPSc) Antibody from MyBioSource.com is a Mouse Monoclonal antibody to AltPrP, CD230, CJD, p27-30, Prn-i, PRNP, PRPC, and Prpsc. This antibody recognizes Sheep antigen. The MOUSE ANTI SHEEP CD230 (PrPSc) Antibody has been validated for the following applications: ELISA, and Immunohistochemistry.
Description
Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques. CD230. also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties. MBS212818 is specific for PrPSc. This clone does not appear to immunostain the normall cellular PrP expressed in heathly sheep tissue sections resulting in specific labelling of ovine PrPSc. This antibody was raised against a synthetic peptide (146-R154R171-182) of the ovine PrP peptide and specificially recognises the R151-R159 sequence